Document 0504
 DOCN  M9480504
 TI    Nuclear localization of foamy virus Gag precursor protein.
 DT    9410
 AU    Schliephake AW; Rethwilm A; Institut fur Virologie und Immunbiologie,
       Wurzburg, Germany.
 SO    J Virol. 1994 Aug;68(8):4946-54. Unique Identifier : AIDSLINE
       MED/94309158
 AB    All foamy viruses give rise to a strong nuclear staining when infected
       cells are reacted with sera from infected hosts. This nuclear
       fluorescence distinguishes foamy viruses from all other retroviruses.
       The experiments reported here indicate that the foamy virus Gag
       precursor protein is transiently located in the nuclei of infected cells
       and this is the likely reason for the typical foamy virus nuclear
       fluorescence. By using the vaccinia virus expression system, a conserved
       basic sequence motif in the nucleocapsid domain of foamy virus Gag
       proteins was identified to be responsible for the nuclear transport of
       the gag precursor molecule. This motif was also found to be able to
       direct a heterologous protein, the Gag protein of human immunodeficiency
       virus, into the nucleus.
 DE    Amino Acid Sequence  Animal  Biological Transport  Cell Line  Cell
       Nucleus/METABOLISM  Cercopithecus aethiops  Fluorescent Antibody
       Technique  Gene Products, gag/*METABOLISM  Hamsters  Human  Mice
       Molecular Sequence Data  Protein Precursors/*METABOLISM  Sequence
       Homology, Amino Acid  Spumavirus/*GENETICS/PHYSIOLOGY  Support, Non-U.S.
       Gov't  Tumor Cells, Cultured  Vero Cells  Virus Replication  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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